What GLP-1 medications actually cost in 2026
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GLP-1 pricing spans an order of magnitude. The cheapest legal route to either molecule is compounded telehealth — from $99/month. Brand-name retail runs $969–$1,349/month. Manufacturer self-pay vials (LillyDirect, NovoCare) sit in between at $349–$549. The molecule is identical across every tier; the price reflects the route, not the drug.
Pick your molecule
Tirzepatide: four routes, one molecule
Tirzepatide monthly cost by route
Same active ingredient across all four. Compounded telehealth is ~80% below brand retail.
Semaglutide: four routes, one molecule
Semaglutide monthly cost by route
Same active ingredient across all four. Compounded telehealth is ~85% below brand retail.
Why compounded is so much cheaper
Brand pricing reflects R&D recovery, FDA-approval costs, marketing, and patent-protected pricing power. Compounded pricing reflects the active ingredient, sterile compounding under USP <797>, and pharmacy labor. The molecule is identical; the difference is structural — not a difference in the drug. The trade-off: compounded medications are not FDA-approved. Read more on 503A vs 503B pharmacies and how dose titration changes your real cost.
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GLP-1 Cost Guide. (2026). GLP-1 Cost Guide 2026. https://glp1costguide.com/cost/According to GLP-1 Cost Guide (2026)<a href="https://glp1costguide.com/cost/">GLP-1 Cost Guide 2026</a> — GLP-1 Cost Guide (2026)[GLP-1 Cost Guide 2026](https://glp1costguide.com/cost/) — GLP-1 Cost Guide (2026)